Pharmacokinetic Interaction Between Bay Leaf (Syzygium polyanthum) Infusion and Captopril in Rats
DOI:
https://doi.org/10.20527/jps.v13i1.23772Keywords:
Captopril, Infusa, Bay Leaf, Syzygium polyanthum, PharmacokineticsAbstract
Captopril, an ACE inhibitor, is commonly prescribed as first-line therapy for hypertension. In practice, patients often combine synthetic drugs with herbal remedies such as bay leaves (Syzygium polyanthum), raising concerns about potential interactions. This study investigated the effect of bay leaf infusion on the pharmacokinetic profile of Captopril in white rats (Rattus norvegicus). Ten rats were divided into two groups: group 1 received 25 mg of Captopril, while group 2 received the same dose in combination with bay leaf infusion. Blood samples were collected via the tail vein at 0; 0.5; 1; 2; 4; 6; 12 and 24 hours, and analyzed using a UV-VIS spectrophotometer (205 nm). Pharmacokinetic parameters assessed included absorption rate constant (ka), elimination rate constant (ke), half-life (t½), peak time (tmax), maximum concentration (Cpmax), and area under the curve (AUC). Results showed that bay leaf infusion increased Cpmax (2.646 → 3.105 µg/ml), prolonged t½ (3.347 → 16.116 h), and elevated AUC (23.382 → 56.479 µg·h/ml). These findings indicate that bay leaf infusion significantly alters the pharmacokinetic profile of Captopril.References
Aulya, Y., & Dahlan, F. M. (2024). Penyuluhan dan pemeriksaan tekanan darah pada wanita lansia hipertensi. Jurnal Peduli Masyarakat, 6(1), 171–178. https://doi.org/10.37287/jpm.v6i1.2598
Bitwell, C., Indra, S. Sen, Luke, C., & Kakoma, M. K. (2023). A review of modern and conventional extraction techniques and their applications for extracting phytochemicals from plants. Scientific African, 19, 1–19. https://doi.org/10.1016/j.sciaf.2023.e01585
Chen, R. J., Suchard, M. A., Krumholz, H. M., Schuemie, M. J., Shea, S., Duke, J., Pratt, N., Reich, C. G., Madigan, D., You, S. C., Ryan, P. B., & Hripcsak, G. (2021). Comparative first-line effectiveness and safety of ACE (angiotensin-converting enzyme) inhibitors and angiotensin receptor blockers: A multinational cohort study. Hypertension, 78(3), 591–603. https://doi.org/10.1161/HYPERTENSIONAHA.120.16667
Cicih, A., Aligita, W., & Susilawati, E. (2022). A review: The pharmacokinetics and pharmacodynamics of metformin–herb interactions. Jurnal Ilmiah Farmasi, 18(1), 13–25. https://doi.org/10.20885/jif.vol18.iss1.art2
Dafriani, P. (2016). Pengaruh rebusan daun salam (Syzygium polyanthum (Wight) Walp.) terhadap tekanan darah pasien hipertensi di Sungai Bungkal, Kerinci 2016. Jurnal Medika Saintika, 7(2), 25–34. https://doi.org/10.30633/782220162017%25p1
Gayatri, A., Ascobat, P., & Setiabudy, R. (2023). Implikasi klinis variasi jumlah copy gen CYP2D6. Generics: Journal of Research in Pharmacy, 3(2), 74–82. https://doi.org/10.14710/halal.v%25vi%25i.19085
Harrison, D. G., Coffman, T. M., & Wilcox, C. S. (2021). Pathophysiology of hypertension: The mosaic theory and beyond. Circulation Research, 128(7), 847–863. https://doi.org/10.1161/CIRCRESAHA.121.318082
Istichomah, I., Ambarwati, E. R., Handayani, S., Wulandari, S. R., Winarsih, W., Lubis, D. P. U., & Heryningsih, W. P. (2024). Edukasi tentang tanaman herbal untuk mengatasi hipertensi di Dusun Sumber Gamol Gamping Sleman. Jurnal Pengabdian Harapan Ibu (JPHI), 6(1), 1–7. https://doi.org/10.30644/jphi.v6i1.849
Jan, R., Khan, M., Asaf, S., Lubna, Asif, S., & Kim, K. M. (2022). Bioactivity and therapeutic potential of kaempferol and quercetin: New insights for plant and human health. Plants, 11(19), 1–18. https://doi.org/10.3390/plants11192623
Jusna, Nasrudin, & Rahman, A. (2022). Fitokimia dan aktivitas antiradikal DPPH seduhan daun kayu jawa (Lannea coromandelica). Sains: Jurnal Ilmu Kimia dan Pendidikan Kimia, 11(1), 35–43. https://sains.uho.ac.id/index.php/journal/article/view/20
Lutfiyati, H., Yuliastuti, F., & Khotimah, A. (2017). Pola pengobatan hipertensi pada pasien lansia di Puskesmas Windusari Kabupaten Magelang. Jurnal Farmasi Sains dan Praktis, 3(2), 14–18. https://doi.org/10.31603/pharmacy.v3i2.1726
Mandasari, U. S., Pratiwi, L., & Rizkifani, S. (2022). Identifikasi penggolongan obat berdasarkan peresepan obat hipertensi di instalasi rawat jalan rumah sakit. Journal Syifa Sciences and Clinical Research, 4(1), 287–296. https://doi.org/10.37311/jsscr.v4i2.14028
Mayasari, S. (2020). Analysis of the use of captopril drug with blood pressure of hypertension patients. Jurnal Kesehatan Dr. Soebandi, 8(2), 123–127. https://doi.org/10.36858/jkds.v8i2.225
Momoniat, T., Ilyas, D., & Bhandari, S. (2019). ACE inhibitors and ARBs: Managing potassium and renal function. Cleveland Clinic Journal of Medicine, 86(9), 601–607. https://doi.org/10.3949/ccjm.86a.18024
Nazri, A. R. M., Siti N., A., Rovina, K., Nor Hayati, M., Mury, K., Abdul Aziz, J., & Huda, N. (2025). Physicochemical analysis of bay leaf (Syzygium polyanthum (Wight) Walp.) and its effect on healthy adults’ blood glucose. Food Research, 9(4), 336–346. https://doi.org/10.26656/fr.2017.9(4).148
Noer, S. F., Irfayanti, N. A., & Rahmat, I. M. (2023). Aktivitas antihipertensi ekstrak etanol daun alpukat (Persea americana Mill.) pada tikus putih (Rattus norvegicus). Media Farmasi, 19(2), 87–95. https://doi.org/10.32382/mf.v19i2.121
Nugrahaningsih, W., & Afanin, S. I. (2022). Farmakokinetika flavonoid ekstrak daun tin pada plasma darah tikus. Life Science, 11(2).* http://journal.unnes.ac.id/sju/index.php/LifeSci
Rachmawati, S. R., & Suriawati, J. (2019). Characterization of moringa (Moringa oleifera Lam.) leaf water extracts by chemical and microbiology. SANITAS: Jurnal Teknologi dan Seni Kesehatan, 10(2), 102–116. https://doi.org/10.36525/sanitas.2019.11
Rasyad, A. A., Noviza, D., & Muslim. (2011). Mikroenkapsulasi kaptopril dengan penyalut etil selulosa menggunakan metoda penguapan pelarut. Jurnal Ilmiah Farmasi, 8(2), 65–74. https://journal.uii.ac.id/JIF/article/view/21947
Rhamadan, R., Restiana, N., & Bahrudin, U. (2022). Penerapan rebusan daun salam untuk menurunkan tekanan darah pada penderita hipertensi di Desa Pasirlaja. HealthCare Nursing Journal, 4(2B), 157–162. https://journal.umtas.ac.id/index.php/healtcare/article/view/2602
Salman, Firawati, Setiawan, D., Nuradi, Muzayyidah, Usman, S., Sari, R. P., Kurniaty, L., Ardiani, R., Firsty, G. R., Deniyati, Ramadhani, F. N., Krisnawati, M., Hasanah, N., Abdullah, R., & Angganawati, R. T. (2024). Farmakokinetika. Eureka Media Aksara.
Saputri, R. S., Mustaqimah, & Hakim, A. R. (2022). Pharmacokinetic interaction of captopril combination with decoction of soursop leaves (Annona muricata L.) in male white rats (Rattus norvegicus) Wistar strain. Jurnal Farmasi Indonesia, 19(2), 339–347. https://doi.org/10.31001/jfi.v19i2.1451
Umar, A. H., & Fajriansyah. (2015). Profil farmakokinetik interaksi obat antidiabetik oral (ADO) dan minuman kopi pada kelinci (Oryctolagus cuniculus) diabetes mellitus. Jurnal Farmasi dan Bahan Alam, 3(2), 41–45.
Unger, T., Borghi, C., Charchar, F., Khan, N. A., Poulter, N. R., Prabhakaran, D., Ramirez, A., Schlaich, M., Stergiou, G. S., Tomaszewski, M., Wainford, R. D., Williams, B., & Schutte, A. E. (2020). 2020 International Society of Hypertension global hypertension practice guidelines. Hypertension, 75(6), 1334–1357. https://doi.org/10.1161/HYPERTENSIONAHA.120.15026
Wahyuni, S. W., Melinda, R., & Rasyad, A. A. (2022). Preparation and characterization submicro particle chitosan and alginate sodium as captopril barrier with chitosan variation. Journal of Pharmaceutical and Sciences, 5(2), 409–416. https://doi.org/10.36490/journal-jps.com.v5i2.118
Downloads
Published
Issue
Section
License
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
.jpg)
